Frequently Asked Questions

How do I use Periogen®?

Periogen is easy to use. Just follow these simple instructions.

How does Periogen work?

Periogen works by preventing the mineralization and interlocking of dental plaque and hence prevents the formation of dental calculus/tartar.

What does Periogen do?

Periogen is an extremely effective tartar softener and inhibitor when used following normal tooth brushing. Periogen has been proven to reduce tartar buildup between cleanings by up to 45%. Dental cleanings are easier for the hygienist and more pleasant for the patient.

What is required for best results?

Periogen performance requires a patient partnership with dentistry; as our impressive anti-calculus research results were on patients who had been scaled within the previous 6 months. 

When should I use Periogen?

Periogen should be used daily, prefererably morning and night until results are achieved after which the frequency of use can be moderated to maintain those results. Periogen should be used as the last step in your oral care regime. Typically, we recommend that you brush, floss, and then rinse or irrigate with Periogen.

How long does it take to see results?

The time required to achieve the desired results can vary with clinical improvement typically seen within 2 to 4 weeks. However, it may take as long as 90 days depending on the individual. 

Can I premix Periogen?

Yes, you may premix the solution and keep it in a sealed container. Please be aware that the rinse will become room temperature. For some people temperature sensitivity plays a part and Periogen may be more comfortable when mixed with warm water.   

Why does Periogen have a 7.5 pH?

The human body tries to regulate the pH of the mouth between 6.7 to 7.3 (a range that is considered neutral and healthy for all practical purposes). The pH range of the average healthy adult mouth is actually between 6.2 to 7.6, depending on an individual's diet and genetics. Even a normal blood pH is 7.4. Most people tend to drive pH down from slightly alkaline (best case) to acidic (worst case, below 7.0) through poor diet and habits.

Sodas, sports drinks, beer, and wine are all acidic. The vast majority of mouthwashes are also acidic with a pH range around 5 or lower. An acidic oral environment causes plaque to calcify and harden into tartar. Tartar is porous,  like a coral reef, and provides a shielding effect for anaerobic bad bacteria (the ones that can live without air and cause gum disease) to grow and thrive. Periogen is formulated at 7.5 pH so as to ensure that the user’s mouth is near 7.0 or higher so that it can soften any hardened tartar.

Are there any side effects to using Periogen? 


What is Periogen made of?

Periogen is made from common FDA-approved food additives (salts) found in countless foods and products. 

How much does Periogen cost to use?

Periogen costs about 7 cents per liquid ounce when mixed with water, making it one of the most inexpensive mouth rinses on the market. One 3 ounce bottle lasts about 45 days when used twice a day. 

Can Periogen harm enamel, dental appliances or adhesives?

No. Periogen is gentle and safe for all dental work, adhesives, and completely non-acidic with a healthy 7.5 pH. 

Can I use Periogen to dissolve tartar off my pet’s teeth?

We have no study to indicate Periogen effectiveness on animals.

Can I mix Periogen with other products?

Do not mix Periogen with other products. This may be unsafe due to a reaction of ingredients from other products. Periogen needs no other product to eliminate germs and dissolve tartar.

May I use more Periogen than the label says?

Yes. The amount of Periogen to use as indicated in the directions is meant to ration the bottle for the maximum amount of applications. There is no limit to how much you can use for a given application.

I was told I have deep pockets. I have 5mm pockets and one 6mm pocket. Can Periogen help?

Yes, Periogen can definitely help by dissolving the tartar that is causing the deep pockets. These pockets should have Periogen applied with an oral irrigator.

Can Periogen clog my oral irrigator like some mouthwashes do?

No. When dissolved, Periogen® goes into solution, and is not a mixture. It is in many ways like a water softener which never clogs oral irrigators.

The ingredients say Periogen has citric acid. Isn’t that too acidic?

No, although Periogen contains citric acid, it also contains a greater amount of sodium bicarbonate. When placed in water, these two chemicals react; creating carbonic acid (a weak acid) and releasing CO2, thus creating effervesces that dissolves the other ingredients into solution. The resulting solution has a healthy pH of 7.5. 

How does Periogen compare with Chlorhexidine (CHX)?

Periogen is a preventative dental measure and makes no claims as a medical treatment for disease. However, independent dental university research has demonstrated that rinsing with Periogen is as effective as rinsing with CHX without the negative side effects and can be used indefinitely. 

What does Periogen taste like?

Periogen (original flavor) has what most consider a neutral taste that is designed to not interfere with the flavor of your favorite toothpaste.

Is Periogen safe to use while pregnant or breastfeeding? 

We have no studies to support whether it is safe to use when pregnant or breastfeeding. However, we believe Periogen is safe and effective unless you have an allergy to one of the FDA-approved food grade ingredients used regularly in the food and dental industries. 

Safety Video