Science of Periogen
Dental calculus or tartar is a calcified mass that forms on the surface of teeth and dental appliance through mineralization of bacterial dental plaque in the mouth. Dental calculus is layered by non-mineralized bacterial plaque; hence act as reservoir of microorganisms in the oral cavity. Periogen is comprised of 4 food-based ingredients: tetrapotassium pyrophosphate, sodium tripolyphosphate, baking soda, and citric acid. When added to water, ingredients baking soda and citric acid add fizz in order to draw the active tartar-dissolving ingredients into solution and to establish a healthy 7.5 pH.
Tetrapotassium pyrophosphate is a colorless transparent crystalline chemical compound with the formula Na4P2O7. It is a salt composed of pyrophosphate and sodium ions. It is the "tartar control" agent which removes calcium and magnesium from the saliva, so they cannot deposit on the teeth. It has been shown that pyrophosphates have a high affinity to hydroxyapatite (HA) surfaces, probably by an interaction with Ca2+ in the hydration layer. By interacting with HA and enamel surface, pyrophosphate reduces their protein binding capacity. It also has the ability to inhibit calcium phosphate formation. It is therefore conceivable that pyrophosphates introduce in the oral cavity through dentifrices may affect pellicle formation. Tetrapotassium pyrophosphate inhibits the mineralization of biofilm before it is transferred into supragingival calculus. Sodium tripolyphosphate is an inorganic compound with formula Na5P3O10. It is a mineral based ingredient that binds the calcium present in saliva and reduces the formation of tartar on the tooth surface.
Worldwide clinical studies showed that the presence of Tetrapotassium pyrophosphate and Sodium tripolyphosphate in Periogen significantly inhibited the development of dental calculus and thus play a major role in establishing complete oral health.