Research Publications

    1. DENTAL CALCULUS: A STRATEGIC REVIEW: International Journal of Dental and Health Sciences, 2014; 1(5):788-795 (PDF)

    “Calculus dissolution based oral rinse like Periogen® (Periogen Company-USA) with key ingredients of Tetrapotassium Pyrophosphate (TKPP), Sodium Tripolyphosphate (STPP), Sodium Bicrbonate, Sodium Fluoride and Citric Acid seems to be potential oral rinse for suppressing the mineralization of dental plaque when used on regular basis as an adjunct to tooth brushing”

    2. A Prospective Experimental Comparative Study on the Clinical Effects of Calculus Dissolution based Oral Rinse in Gingivitis Patients. International Journal of Experimental Dental Science, January-June 2015; 4(1):33-39 (PDF)

    “The results of the present study are intriguing and should be interpreted from a clinical perspective. Dentist/hygienists should prescribe anticalculus oral rinse (Periogen®) between the professionally cleaning of teeth. This could be a practice that would decrease the bio load in the oral cavity specially the new calculus deposits that serves as reservoir to dental plaque”

    3. Oral Irrigation Study (Water Flosser) - Periogen® Oral Rinse Study to Determine the Effect of Periodontal Disease. International Dental Journal 2015; 65 (Suppl. 2): 108--161 (PDF)

    “In conclusion, Periogen® oral rinse is significantly better in reducing periodontal disease as compared to just using a water flosser alone”

    4. A Prospective Experimental Comparative Study on the Clinical Effects of Calculus Dissolution Based Oral Rinse in Gingivitis Patients. International Dental Journal 2015; 65 (Suppl. 2): 108--161

    “Regular home use of oral rinse with anti-calculus properties will be effective to prevent mineralization and further suppress calculus formation in order to prevent gingival inflammation”

    5. Peri-Implantitis and Biofilm: Inescapable Bio-Linkage: Journal of Oral Hygiene and Health, 2015; 3(1):11 (PDF)

    “Recent advances with next generation anti-calculus mouth rinse such as Periogen® will play a key role in preventing peri-implantitis”

    6. Dental Calculus: A Bacterial Hub. Journal of Dental problem and Solutions, 2016; 3(1):6 (PDF)

    “Technology and research today provide openness to safe, affordable and effective anti-calculus Mouth rinse (Like Periogen®) that can be a potential turning point in maintaining oral hygiene”

    7. Periodontal Disease Linked to Erectile Dysfunction. J Oral Bio. 2016; 3(1):1 (PDF)

    "A recently conducted clinical study proved that mouth rinse (Periogen®) containing tetrapotassium pyrophosphate and sodium tripolyphosphate as the anticalculus agent provides a clinically relevant reduction in calculus formation"

    8. A Six-Month Clinical Study to Evaluate the Effects of Sodium Tripolyphosphate and Tetrapotassium Pyrophosphate Based Calculus Dissolution Oral Rinse in Patients with Zirconium Dioxide and Titanium Dental Implants BEMS Reports, 2016;2(2):64-70 (PDF)

    “Calculus dissolution based Periogen® mouthrinse provided clinically significant reduction in calculus formation in subjects with zirconium dioxide and titanium dental implants when used twice daily for 6 months as an adjunct to toothbrushing”

    9. Anti-Plaque And Antimicrobial Efficiency Of Different Oral Rinses in a 3-Day Plaque Accumulation Model. J Biol Reg Homeos Ag 2016; 30 (4):1173-78 (PDF)

    “From the public health point of view, Periogen® mouthwash can serve as a good alternative to avoid alcohol based products or those with an artificial preservatives”

    10. Maturation Index Assessment of Sodium Tripolyphosphate and Tetra Potassium Pyrophosphate Based Calculus Dissolution Mouthrinse (Periogen®) in Moderate Gingivitis Patients: A Histopathological Study. J Dent Health Oral Disord Ther 2017, 6(6):00218 (PDF)

    “Periogen® mouth rinse play a significant role in plaque control; accelerate in gingival wound healing by increasing turnover of superficial cell number”

    11. Rajnics Z, Radnai M. The Effect of Periogen® Solution on Dental Calculus in vitro: A Pilot Study. Int J Experiment Dent Sci 2017; 6(1):33-34 (PDF)

    “The experiment showed that pulverizing the previously hard calculus was done easily after soaking it in Periogen®”

    12. Comparative Effect of Chlorhexidine and Anti-Calculus Mouthrinse on Dental Plaque, Gingival Inflammation and Calculus Formation on Plaque Induced Gingivitis Patients. BEMS Reports. 2017;3(1):1-5 (PDF)

    "Periogen effectively reduced the clinical symptoms of plaque-induced gingivitis, and had a statistically significant effect on the reduction of clinical and salivary concentration parameters when compared to 0.12% Chlorhexidine."

    13. The Efficacy of Anticalculus Mouth Rinse in Moderate Gingivitis Patients with and without Professional Intervention. J Int Oral Health 2018; 10:148-51 (PDF)

    “Periogen used in this study was effective in controlling plaque and calculus with a statistically significant manner both with and without professional intervention when used regularly”

    14. Evaluation and Comparison of Patient Feedback on Chlorhexidine Vs Anti-Calculus Mouthrinse after 6 Months of Compliance (PDF)

    15. The Effect of Anti-Calculus Oral Spray on Oral Hygiene Status of Gingivitis Patients: A 6 weeks observational study (PDF)


    17. Efficacy of bioactivated anticalculus toothpaste on oral health: a single-blind, parallel-group clinical study (PDF)

    18. Efficacy of a Rinse Containing Tetrapotassium Pyrophosphate and Sodium Tripolyphosphate on Calculus Formation in a Group of Adults (PDF)